RediScore®
The RediScore® test is largely suggested for all patients with ovarian cancer, as well as in cases where PARP inhibitor therapy is being explored for treatment or maintenance.
The examination will assist the physician in exploring the potential of
- For specified medicine in ovarian carcinoma
- For off-label use of medication in breast, pancreatic, and prostate cancers, as well as other solid tumors.
What is the significance of the RediScore Test?
Multiple clinical studies have demonstrated that approximately 50% of ovarian cancer patients may benefit from PARP inhibitor therapy. These encompass patients with:
- BRCA1 and BRCA2 mutations
- Tumors exhibiting homologous recombination deficit (HRD)
- Since 2014, the FDA has approved four PARP inhibitors: Olaparib, Niraparib, Rucaparib, and Talazoparib. Their administration has received approval for four cancer types: ovarian, prostate, pancreatic, and breast cancer.
Exemplary Outcomes Report
What is the meaning of HRD?
HRD (Homologous Recombination Deficiency) refers to the cell’s incapacity to repair damage via the homologous recombination mechanism. Genomic instability signifies a deficiency in the HR pathway.
Three biological parameters, referred to as ‘genomic scars,’ are utilized for its calculation
- Loss of Heterozygosity (LOH)
- Telomeric Allelic Imbalance (TAI)
- LST – Large Scale Transitions
The BRCA1 and BRCA2 genes are essential for the effective operation of homologous recombination. Tumors with germline and/or somatic mutations in these genes exhibit a deficit in the homologous recombination process. Human Resource Development (HRD). The assessment of Homologous Recombination Deficiency (HRD) is conducted through
The examination of tumor mutations in the BRCA1 and BRCA2 genes
The assessment of genomic instability (GIS) across the genome.
The RediScore® test is largely suggested for all patients with ovarian cancer, as well as in cases where PARP inhibitor therapy is being explored for treatment or maintenance.
The results will be provided within 15 business days, next business day after the sample is delivered to the laboratory.
For the Rediscore test, we require paraffin blocks from the tumor or alternatively, uncolored paraffin slices affixed to slides.
Payment may be executed via bank transfer or Cash
Please reach out to the Customer service concerning the reception of the sample. The results are communicated to both you and your doctor by email.
Our Customer Service Team is dedicated to addressing your inquiries concerning the services provided by Genekor. To order any tests conducted by Genekor, please contact us directly.
